Open access
Aug 2026
Structural basis for covalent inhibition of sulfatases by sulfamate warheads
The enzymatic removal of sulfate groups regulates processes ranging from steroid metabolism to carbohydrate degradation. Most sulfatases belong to the S1 family, whose members use a co-translationally installed formylglycine residue to hydrolyse sulfate esters. Arylsulfamates are potent covalent inhibitors of aryl and...
C. Tomlinson, Stefano Elli, Morgan Batiste-Simms et al.
· bioRxiv · 0 citations