Lai-En Shen

Ciprofol induces ferroptosis and enhances anti-PD-1 efficacy via USP1-mediated GPX4 ubiquitination in hepatocellular carcinoma

Immune checkpoint inhibitors targeting the PD-1/PD-L1 axis have shown promise in hepatocellular carcinoma (HCC), but resistance due to the immunosuppressive tumor microenvironment remains a major challenge. Ferroptosis, an iron-dependent form of regulated cell death, has emerged as a potential strategy to enhance anti-...