Open access
Aug 2026
LPA1-Induced EMT of Retinal Pigment Epithelial Cells Promotes Subretinal Fibrosis via USP1-Mediated Deubiquitination and Stabilization of ZEB1
Purpose Subretinal fibrosis (SRF) is a vision-threatening complication of neovascular age-related macular degeneration (nAMD), yet effective antifibrotic strategies remain limited. This study investigated the role of lysophosphatidic acid receptor 1 (LPA1), a fibrosis-associated G protein–coupled receptor, in SRF progr...
Manhui Zhu, Liang Cui, Yang Guo et al.
· Investigative Ophthalmology... · 0 citations