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Open access Jul 2026

Synthesis of thiosemicarbazone derivatives of thiophene-2-carboxylic acid as potent urease inhibitors: in vitro evaluation, molecular docking, and density functional theory analysis.

AIMS To synthesize and evaluate a series of thiosemicarbazone derivatives (2a-2g) incorporating thiophene-2-carboxylic acid as urease inhibitors. MATERIALS AND METHODS The compounds were synthesized and characterized using modern spectroscopic techniques. In vitro urease inhibition was determined followed by computat...

W. Khan, Laiba, Imtiaz Ahmad et al. · 0 citations

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