Author

Laila Stoddart

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Open access Oct 2026

IL-6 Blockade with Clazakizumab is Associated with Low Myeloid Cell Activation and Increased Type 2 Immune Responses in Non-survivors of COVID-19.

BACKGROUND IL-6 inhibitors have been associated with reduced mortality in severe COVID-19 in randomized clinical trials, but the comprehensive immunological impact of IL-6 blockade in the setting of an acute viral infection is poorly understood. METHODS To gain insight into the systemic immune response to IL-6 inhibi...

Laila Stoddart, T. Johnston, Wei-Qiang Zhou et al. · Journal of Infectious Diseas... · 0 citations

Open access Sep 2026

Balancing lipid synthesis and oxidation promotes B cell response to vaccination during immunosuppression.

Pharmacologic immunosuppression is essential for preventing organ rejection and controlling autoimmunity, but profoundly impairs humoral immunity, increasing the risk of vaccine failure and infection. The mechanisms by which immunosuppressive therapies disrupt human B cell responses remain poorly defined. Here, we iden...

Elizabeth A. Thompson, Alexis Figueroa, Katerina Roznik et al. · Journal of Clinical Investig... · 0 citations

Open access Jul 2026

Conserved CD4 T-cell responses correlate with antibody neutralization in solid organ transplant recipients after bivalent SARS-CoV-2 vaccination

The results emphasize the importance of conserved and cross-reactive responses in vaccine immunogenicity, providing a mechanism through which repeated boosting enhances vaccine immunogenicity in SOTRs and other immunocompromised populations.

Georgia Stavrakis, Katerina Roznik, Laila Stoddart et al. · Frontiers in Immunology · 0 citations