Lalima K. Madan

Distinct Conformational Switches Control WPD-Loop Dynamics Across Protein Tyrosine Phosphatase Subfamilies.

Protein Tyrosine Phosphatases (PTPs) regulate cellular signaling by balancing phosphotyrosine levels through a conserved WPD-loop that switches between open (inactive) and closed (active) conformations. While this conformational change is crucial for catalysis, the structural factors governing this motion remain poorly...