SHMT2 Regulates T Cell Homeostasis and Mucosal Inflammation Via Metabolic and Lipid Remodeling 2256280
The loss of SHMT2 in T cells disrupted mitochondrial one-carbon metabolism, induced redox imbalance and enhanced neutral lipid storage and phospholipid synthesis, with compensatory arginine-proline upregulation and taurine depletion to sustain survival under oxidative stress.