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Aug 2026

Robust annotation and discovery of novel cell types in single-cell ATAC-seq data through cross-modal reference alignment.

CARA is introduced, a cross-omics Bayesian framework that transfers cell type knowledge from scRNA-seq to scATAC-seq and detects novel cell types in single-cell DNA methylation data, demonstrating seamless extensibility to new modalities.

Lan Cao, Wenhao Zhang, Feng Zhou et al. · 0 citations
Open access Aug 2026

ScanNet: Single-cell annotation informed by transcriptional regulation Network via iterative heterogeneous graph learning

The ScanNet framework is a scalable, transferable, and mechanistically informed framework for accurate cell type annotation across diverse single-cell data modalities and can be flexibly transferred to single-cell ATAC-seq data by mapping chromatin accessibility to gene level.

Yongyu Long, Wenhao Zhang, Lan Cao et al. · 0 citations

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