Pathological regulation of endothelial-to-mesenchymal transition in cardiac fibrosis through signaling pathways and exosomal microRNA crosstalk.
Cardiac fibrosis is a central pathological feature of many cardiovascular diseases and contributes to progressive myocardial remodeling and heart failure. Among the diverse cellular sources of activated fibroblasts, endothelial cells have emerged as a significant contributor through endothelial-to-mesenchymal transitio...