Author

Landon M. Clark

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Open access Oct 2026

Transcriptionally distinct atypical B cell populations contribute to insulin autoreactivity and show differential activation, isotype switching, and somatic hypermutation in early-stage type 1 diabetes individuals

Autoreactive B cells must escape immune tolerance mechanisms to drive autoimmune disease, potentially through alternative paths to memory and antibody-secreting cell formation. “Atypical” B cells represent one such alternative pathway and are expanded in several human autoimmune diseases. Atypical B cells display pheno...

Lindsay E. Bass, Landon M. Clark, Bryan Han et al. · bioRxiv · 0 citations

Open access Aug 2026

SAP loss limits anti-insulin atypical B cell activation and pro-inflammatory CD8 T cells despite preserved Tfh responses to protect against type 1 diabetes

The essential role of SAP in mediating proinflammatory, anti-insulin B-T interactions to support T1D is highlighted, which led to reduced pro-inflammatory CD8+ T cell formation and islet-reactive progenitor exhausted CD8+ T cells in pancreata.

Landon M. Clark, Dudley H. McNitt, Jack C. McAninch et al. · bioRxiv · 0 citations