Author

Lanlan Han

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Open access Jul 2026

An Integrated Transcriptional and Post-Transcriptional Regulatory Circuit Orchestrated by NUDT21 Maintains the Proliferation and Survival of Neuroblastoma.

BACKGROUND Neuroblastoma (NB) is the most prevalent pediatric solid tumor, associated with a poor prognosis. While alternative polyadenylation (APA) is a key post-transcriptional regulatory mechanism in many cancers, its role in NB remains largely unexplored. METHODS We used public expression profiles from NB and nor...

Yang Yang, Chunxia Shi, Jian-Wei Wang et al. · Neuro-Oncology · 0 citations

Open access Aug 2026

Toward an Understanding of the Mechanistic Differences Between the Hydroxylating and Desaturating Pyridoxal 5′‐Phosphate‐Dependent L‐Arginine Oxidases

Pyridoxal‐5′‐phosphate (PLP)‐dependent L‐arginine oxidases (PDAOs) catalyze 4‐electron oxidations of L‐arginine in the context of secondary metabolite biosynthesis. PDAOs are separated into two classes based on whether they hydroxylate or desaturate L‐arginine. A detailed mechanistic understanding of these enzymes will...

Trevor R Melkonian, Nemanja Vuksanović, Lanlan Han et al. · ChemBioChem · 0 citations