Review
Open access
Jan 2026
Mutation Severity of FBXO43 Determines Spermatogenic Outcome and Informs Precision ART Strategies
Different types of FBXO43 mutations generate distinct infertility phenotypes through a dose‐dependent mechanism: Truncating mutations cause profound meiotic arrest and NOA, whereas hypomorphic missense mutations permit meiotic completion but result in severe teratozoospermia with high aneuploidy.
Yanqin Xiao, Yutong He, Lanlan Meng et al.
· Human Mutation · 0 citations