Open access
Jul 2026
The nonpeptide angiotensin-(1-7) mimic AVE0991 attenuates neuroendocrine and behavioral responses to chronic unpredictable stress.
These findings validate the CUS model and demonstrate that activation of the Mas receptor by AVE0991 exerts anxiolytic, antidepressant, and neuroprotective effects, supporting its potential as a therapeutic strategy for stress-related neuropsychiatric disorders.
M. L. Fonseca, Laura Beatriz de Oliveira Amaral, Sthéfanie C A Gonçalves et al.
· Psychopharmacology · 0 citations