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Author

Laura Blenkarn

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Jul 2026

Abstract PR010: Targeted degradation of cyclin T1 constrains transcription elongation and triggers tumour cell apoptosis

Transcriptional dysregulation is a hallmark of cancer and is frequently driven by oncogenic alterations that rewire downstream gene-expression programmes. Although kinase inhibitors targeting upstream oncogenic drivers can produce clinical benefit, responses are often limited by acquired resistance and pathway adapta...

Janice Wenzheng Neng, Laura Blenkarn, Laura S. Itzhaki et al. · 0 citations
Jul 2026

Abstract B045: Targeted degradation of cyclin T1 constrains transcription elongation and triggers tumour cell apoptosis

It is demonstrated that selective degradation of CCNT1 can effectively collapse pTEFb-dependent transcriptional programmes and compromise tumour cell fitness, which may offer a more selective and durable route for therapeutic intervention in transcriptionally dependent tumours.

Janice Wenzheng Neng, Laura Blenkarn, Laura S. Itzhaki et al. · 0 citations

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