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Laura C. Michaelis

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Open access Sep 2026

Mitochondrial Genomic Alterations in Pediatric Acute Lymphoblastic Leukemia: Implications for Methotrexate‐Induced Neurotoxicity and Ethnic Disparities

Methotrexate (MTX)‐induced neurotoxicity is a serious complication in pediatric acute lymphoblastic leukemia (ALL), with observed ethnic disparities in risk. To investigate the role of mitochondrial DNA (mtDNA) variation, we performed whole mtDNA sequencing in 94 children with ALL, including 62 Hispanic patients. We id...

Jing Han, Shahram Arsang-Jang, Paul L. Auer et al. · 0 citations
Sep 2026

Targeting CD38 with bispecific antibody XmAb 18968 in patients with relapsed/refractory acute myeloid leukemia and T-cell acute lymphoblastic leukemia.

XmAb18968 is safe and tolerable with encouraging preliminary efficacy, supporting further investigation of CD38 targeting therapies in this setting, and further investigation of CD38 targeting therapies in this setting is supported.

G. S. Guru Murthy, B. Shah, Talha Badar et al. · 0 citations

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