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Laura E. Baker

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Open access Sep 2026

A Dynamically Regulated Designed IL-2 for Tumor-localized Signaling

Cytokines mediate cell-cell communication to coordinate immune responses and hold clinical promise as immunotherapies1–3. While natural cytokines are exquisitely regulated by immune cells, engineered cytokines have not yet matched this sophisticated regulation, limiting clinical efficacy and safety4,5. IL-2 is an impor...

H. Moffett, Brian D. Weitzner, Michelle M. Lissner et al. · 0 citations

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