Author

Laura Perin

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Open access Sep 2026

Physiological Reference Mapping Reveals Context-Dependent Dysregulation of Regenerative Programs in Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) involves chronic degeneration and regeneration, causing dystrophic muscle stem cells (MuSCs) to differ from uninjured wild-type tissue. Conventional disease-versus-resting-control comparisons may therefore conflate dysregulation with regeneration. We developed a physiological reference...

Laura Perin, Yan-Yun Liu, Gregory A. Brent et al. · Cells · 0 citations

Sep 2026

Dickkopf-1 (DKK1) controls papillary and follicular thyroid cancer growth.

Thyroid cancer, the most frequent endocrine tumor, has a good prognosis. However, the survival rate of patients with recurrent or metastatic forms that become resistant to conventional treatments, drops to less than 20% at 10 years, with a mean life expectancy of 3-5 years. The molecular mechanisms that drive the advan...

Gloria Fiorentino, Beatrice Latiano, Letizia Rinella et al. · Endocrine-Related Cancer · 0 citations