Open access
Sep 2026
Association of high tumor mutational burden with brain metastases: Insights from a large-scale database analysis.
BACKGROUND Brain metastases (BrM) are a major cause of cancer-related mortality. To successfully colonize the brain, cancer cells must acquire unique adaptations. We hypothesized that BrM, regardless of their primary tumor origin, share convergent molecular features enabling brain colonization while retaining tumor typ...
Marana Abboud, S. Sisoudiya, Benjamin Kaplan et al.
· Neuro-Oncology · 0 citations