Open access
Jul 2026
Chromosome-scale CRISPR screening reveals secretory pathway genes as drivers of aneuploidy-mediated antifungal tolerance
This work functionally dissects one of the most common aneuploidies observed in C. albicans, provides mechanistic insight into the molecular basis of antifungal tolerance, and establishes a generalizable framework for studying aneuploidy-mediated phenotypes across eukaryotic organisms.
Nicholas C. Gervais, Lauren F. Wensing, Manini Chhina et al.
· bioRxiv · 0 citations