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Author

Lauren K. Yum

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Open access Sep 2026

Sequential invasion of epithelial and immune cells in Shigellosis

Shigella flexneri, the agent of shigellosis, invades the colonic mucosa, which leads to mucosal erosion, blood and immune cell infiltration, culminating in the hallmark of the disease, bloody diarrhea. Here, we conducted a microscopy-based analysis of time-resolved infection experiments in the infant rabbit model of sh...

Niti B. Jadeja, Brittany A. DeVasure, Lauren K. Yum et al. · 0 citations
Open access Sep 2026

Shigella flexneri undergoes niche-specific adaptation during infection

Shigella flexneri is a leading cause of diarrheal disease worldwide, yet bacterial factors required within distinct host niches remain poorly understood. Here, we used genome-wide transposon sequencing in an infant rabbit model of shigellosis to identify genes promoting bacterial fitness in vivo. The screen identified...

Yuang Sun, D. Lazinski, Lauren K. Yum et al. · 0 citations

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