Designer CASCAD (CARD Assembly on SCAffold DNA), a self-assembled DNA nanoplatform that spatially organizes caspase recruitment domains (CARDs), exhibiting catalytic intracellular caspase-9 activation, is reported, establishing CASCAD as versatile and programmable DNA nanomaterial for reconstructing signaling pathways...
Dhanush Gandavadi, A. Dwivedy, Revathi Manoharaan et al.· bioRxiv· 0 citations
With continued advances in structural design, ligand functionalization, and immune engineering, DNA nanotechnology holds the potential to reshape cancer immunotherapy and pave the way for highly targeted, personalized, and effective treatments that outperform current clinical approaches in specificity, efficacy, and sa...
This work develops a potential method to construct more biostable DNA nanostructures and 3D crystals in a simple one-tube process by assembly of a wide variety of DNA nanostructures and 3D crystals in a hydrated ionic liquid instead of magnesium at constant moderate temperatures.
