Author

Laurent Mely

2 papers indexed here

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Open access Sep 2026

Epigenome-wide association study and functional analyses reveal regulatory loci linked to lung function and diabetes in cystic fibrosis

While the genetic basis of cystic fibrosis is well-established, the genotype alone does not explain the substantial inter-individual variability in disease expression, particularly in pulmonary outcomes. Non-hereditary factors, such as epigenetic modifications, may contribute to this clinical heterogeneity....

Loréna Valdés, Jörg Tost, I. Rivals et al. · Respiratory Research · 0 citations

Open access Aug 2026

Peripheral muscle dysfunction persists in the era of highly effective CFTR modulators in cystic fibrosis.

BACKGROUND Peripheral muscle dysfunction is a well-established extrapulmonary manifestation of cystic fibrosis (CF), contributing to exercise intolerance and reduced quality of life. However, its persistence in the era of highly effective CFTR modulator therapy (HEMT) remains unclear. METHODS Fifty-six people with CF...

A. Bronstein, Elise Zitta, O. Saidi et al. · Journal of Cystic Fibrosis · 0 citations