Review
Open access
Aug 2026
A novel bone and cancer cells co-culture methodology to model breast cancer metastasis to bone ex vivo
An ex vivo co-culture protocol for modeling bone metastasis that enables direct investigation of cancer cell interactions with the native bone and marrow microenvironment and enables high-throughput functional interrogation of cancer colonization in a complex microenvironment is presented.
Ricardo Romero-Moreno, Courtney L. Flatt, Madeline P. Sheeley et al.
· BMC Methods · 0 citations