Open access
Aug 2026
Multi-omics integration identifies APOE as a metabolic regulator of macrophage-fibroblast crosstalk in idiopathic pulmonary fibrosis
A two-sample Mendelian randomization analysis indicated that genetic liability to AD is associated with a lower risk of developing IPF, and APOE functions as a vital metabolic barrier against pro-fibrotic macrophage polarization in the lung.
Bing Bai, Le Chang, Zhi Cheng et al.
· Frontiers in Immunology · 0 citations