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Open access Aug 2026

Multi-omics integration identifies APOE as a metabolic regulator of macrophage-fibroblast crosstalk in idiopathic pulmonary fibrosis

A two-sample Mendelian randomization analysis indicated that genetic liability to AD is associated with a lower risk of developing IPF, and APOE functions as a vital metabolic barrier against pro-fibrotic macrophage polarization in the lung.

Bing Bai, Le Chang, Zhi Cheng et al. · 0 citations

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