Self-assembly of paclitaxel and cyclosporine A to overcome tumor drug resistance.
The clinical application of paclitaxel (PTX) is frequently hindered by multidrug resistance driven by the overexpression of P-glycoprotein (P‑gp). To cooperatively overcome the challenges of drug efflux and tumor resistance, we designed a Zn2+‑coordinated supramolecular self‑assembly strategy, successfully integrating...