Author

Leyi Wei

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Open access Sep 2026

Comprehensive evaluation of structural variation detection for germline and somatic analysis with long-read sequencing data

Abstract Detecting structural variations (SVs) via long-read sequencing remains difficult due to algorithmic variations and genomic complexity, alongside a shortage of comprehensive benchmarks for somatic variants. We present a unified benchmarking framework covering both germline and somatic SV detection, which evalua...

Hua Shi, Yi-Hang Lin, Da-Chen Liu et al. · Briefings in Bioinformatics · 0 citations

Aug 2026

Hyp-retro: hypernetwork-guided preference-conditioned retrosynthetic planner.

Experimental results show that Hyp-Retro outperforms comparative methods in terms of search success rate and route yield, and it can adaptively adjust its planning strategy under different yield preferences, thereby generating high-quality retrosynthetic routes that better satisfy target-specific requirements.

Jing-Wen Wang, Shuan Liu, Shao-Ye Zhang et al. · Molecular diversity · 0 citations

Jul 2026

PeptideSGCL: Structure-Enhanced Graph-Transformer Encoding and Dual-Level Contrastive Learning for Peptide Property Prediction.

A multimodal dual-contrastive learning framework for peptide property prediction is proposed, which improves both the structural encoder and the contrastive learning strategy to enhance the quality of joint sequence-structure representations.

Jiajie Cai, Shuwen Xiong, Yuntao Yang et al. · ACS Synthetic Biology · 0 citations