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Author

Le-Zhen Xu

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2 papers indexed here

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Open access Sep 2026

Association and Mechanistic Insights Linking Bisphenol A to Psoriasis: Integrative Analysis of Bulk Transcriptomics, Network Toxicology, Mendelian Randomization and Single‑cell RNA Sequencing

Purpose Psoriasis is a chronic immune-mediated skin disease with complex etiology, and environmental factors such as bisphenol A (BPA) exposure are suspected pathogenic factors. This study aimed to identify potential diagnostic biomarkers linking BPA exposure to psoriasis and to explore the latent interaction and mecha...

Le-Zhen Xu, Lin-Xue Li, Wen Shi et al. · 0 citations
Open access Aug 2026

Integrated InPETM drug analysis and transcriptomics to explore potential mechanisms and key active components of multiple traditional Chinese medicine prescriptions for psoriasis.

Core herbs and their key active compounds, especially Quercetin and Kaempferol, may be associated with potential anti-psoriatic effects through interactions with IL6, IL1B, MMP9, and JUN, and their involvement in immune, inflammatory, and epidermal proliferation-related pathways.

Le-Zhen Xu, Jingyu Zhao, Lin-Xue Li et al. · 0 citations

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