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Author

Leah C. Kottyan

2 papers indexed here

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Open access Sep 2026

Functional characterization of viral transcriptional regulators reveals extensive rewiring of host pathways

Viral transcriptional regulators (vTRs) reprogram host gene regulatory networks to promote replication, persistence, and immune evasion. Despite the identification of hundreds of vTRs in human viruses, how they rewire host pathways remains unclear. Here, we systematically profiled 95 vTRs from diverse human viruses acr...

Jaice T. Rottenberg, Xing Liu, M. Y. ElSadec et al. · 0 citations
Open access Jul 2026

Single-nuclei multiome-seq and modeling of intestinal cell types nominates regulatory mechanisms driving IBD genetic risk and anti-TNF nonresponse 2309915

The authors' integrated modeling nominates cell-type-specific regulatory mechanisms linking IBD genetic risk to TNFi non-response and prioritizes next-gen IBD biologic targets.

Zi F. Yang, J. Wayman, Elizabeth Angerman et al. · 0 citations

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