Author

Leandro Quadrana

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Open access Aug 2026

Evolution of transposons as controlling elements

Transposons were originally described as “controlling elements,” yet the molecular basis and evolutionary origin of their transcriptional regulatory activities remain elusive. Here, we show that transcriptional regulatory activity is an intrinsic property of transposases (TPases). We demonstrate that the Arabidopsis At...

Taku Sasaki, Carles Borredá, S. Fujii et al. · bioRxiv · 0 citations

Sep 2026

GH1-HMGA proteins restrict RNA-directed DNA methylation and antagonize linker histone H1 at euchromatic transposable elements

How GH1-HMGA proteins specifically restrain RdDM activity at euchromatic TEs is revealed and how the H1/GH1-HMGA balance spatially partitions distinct DNA methylation pathways across the genome is elucidated.

Lea Feit, Alejandro Edera, Emmanuel Vanrobays et al. · bioRxiv · 0 citations

Open access Aug 2026

A functional atlas of transposon-encoded products and their integration into host networks

It is shown that control of TE expression and propagation is deeply embedded within host regulatory circuits, with DNA methylation and transcription factors jointly shaping TE transcriptional activity.

Carles Borredá, Pol Vendrell-Mir, Basile Leduque et al. · Nature Communications · 1 citation