Plasma ACTH Precursors measured by Pro-opiomelanocortin (POMC) ELISA as a Predictor of Silent Corticotroph Adenomas.
BACKGROUND Silent corticotroph adenomas (SCAs) are only identified after surgical removal and pathological analysis. Defective processing of pro-opiomelanocortin (POMC) may underlie these tumors' failure to secrete biologically active ACTH. While prior studies found elevated plasma POMC in patients with Cushing disease...