Author

Lei Chen

2 papers indexed here

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Sep 2026

CDKL1 facilitates tumorigenesis and metastasis of bladder urothelial carcinoma by activating SIRT1/Wnt/β-catenin signaling.

Bladder urothelial carcinoma (BUC) is a common malignancy characterized by high recurrence and progression, and patients with advanced disease often have poor outcomes due to therapeutic resistance and limited targeted treatment options. In this study, we investigated the role of cyclin-dependent kinase-like 1 (CDKL1)...

Hua-Jun Tan, Yun Zhang, Yong-Qi Long et al. · Urologic oncology · 0 citations

Open access Aug 2026

Development and validation of a two-gene urine DNA methylation assay for noninvasive prostate cancer detection: a prospective multicenter study

Prostate-specific antigen (PSA) screening lacks specificity, particularly within the 4–10 ng/mL diagnostic gray zone, leading to unnecessary prostate biopsies and overtreatment. Here, we developed and validated a streamlined urine DNA methylation assay for non-invasive prostate cancer (PCa) detection and biopsy decisio...

Dingwen Liu, Lian Tang, Wei Xiong et al. · Molecular Biomedicine · 0 citations