H3K18 histone lactylation mediates hypoxia-induced FBXW11 upregulation and supports proliferative and self-renewal-associated properties of hair follicle stem cells.
Hair follicle stem cells (HFSCs) reside in a relatively hypoxic niche and preferentially use glycolytic metabolism, but how metabolic adaptation is coupled to epigenetic regulation of HFSC function remains incompletely understood. Since oxidative phosphorylation produces more reactive oxygen species (ROS) than glycolys...