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Open access Sep 2026

Long-PVSUNet: A Longitudinal Deep Learning Framework for Count-Oriented Perivascular Space Segmentation in Brain MRI.

Enlarged perivascular spaces (ePVS) are small, sparse MRI-visible markers of cerebral small vessel disease and brain ageing. Their size, low contrast, and severe foreground-background imbalance make automated segmentation challenging. Existing methods are mainly cross-sectional and do not model temporal consistency, li...

S. Hayashi, Lei Fan, Jiyang Jiang et al. · 0 citations
Open access Sep 2026

White matter and subcortical MRI markers of subsequent cognitive decline in late-life depression: A two-stage study.

BACKGROUND Late-life depression (LLD) is associated with increased risk of cognitive decline and dementia, yet clinically relevant neuroimaging markers of short-term cognitive decline remain uncertain. METHODS We conducted a two-stage study. In the Shanghai Action to Prevent the Elderly from Dementia (SHAPE) cohort,...

Chaoyue Guo, Yuan Fang, Qi Qiu et al. · 0 citations

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