Sep 2026
Nrf2 overexpression ameliorates cognitive deficits and neuronal damage in APP/PS1 mice via attenuation of Aβ deposition and neuronal ferroptosis.
Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) deposition, yet the mechanisms underlying Aβ-induced neuronal damage remain elusive. Emerging evidence implicates ferroptosis, an iron-dependent form of regulated cell death, in AD pathology. We hypothesized that dysfunction of the Nrf2 pathway critically l...
Xing Zhu, Jin-Yao Bo, Yu-Lu Qian et al.
· Neuroscience Letters · 0 citations