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Open access Oct 2026

Curcumin Enhances the Sensitivity of 5-fluorouracil-resistant Colon Cancer Cells to 5-fluorouracil Through a Ferroptosis-related Mechanism: A Network Pharmacology and In Vitro Study

Colorectal cancer (CRC) is a common and deadly malignancy. Although 5-fluorouracil (5-FU) continues to be a standard therapeutic agent for CRC, the development of resistance substantially compromises its clinical effectiveness. Curcumin, a natural polyphenol, has shown potential in reversing chemoresistance, possib...

Wei Hao, Bang-Wei Cao, Lei Han · 0 citations

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