Open access
Sep 2026
CAFs-mediated histone lactylation reprograms cholesterol metabolism in colorectal cancer to drive CD8+ T cell immunosuppression.
The central role of the CAF-CRC cell-CD8+ T cell regulatory axis is systematically elucidates: CAF-derived lactate modulates cholesterol metabolism in CRC cells via histone lactylation, thereby triggering mitochondrial dysfunction and driving the cellular senescence process.
Hua-Chi Li, Jun-Jie Hu, Lei Huang et al.
· Journal of Pathology · 0 citations