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Open access Aug 2026

lncRNA TUG1 mediates palmitic acid-induced neuronal lipotoxic injury via the miR-449a-5p/caspase-3 and Akt/GSK-3β axes

A close relationship exists between excessive lipids and structural and functional brain dysfunction, with the long non-coding (lncRNA)-microRNA (miR)-mRNA network having an emerging role. Given the increasingly recognized role of the lncRNA taurine upregulated gene 1 (TUG1) in metabolic and neurodegenerative diseases,...

Yang-Wa Wei, Peng-Yao Chen, Xin Zheng et al. · 0 citations
Aug 2026

Protocatechuic Acid Protects Neural Stem Cells against Cerebral Ischemia-Reperfusion Injury by Suppressing JAK2/STAT3 Signaling and Restoring Mitophagy.

BACKGROUND AND OBJECTIVES Neural stem cells (NSCs) are important for endogenous brain repair but are highly vulnerable to mitochondrial dysfunction during cerebral ischemia-reperfusion injury (CIRI). Preliminary bioinformatics analysis suggested that immune microenvironment remodeling and JAK/STAT signaling activation...

Mengzhen Wei, Jie-Jie Hu, Yanxing Ding et al. · 0 citations

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