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Author

Leila Sharifi

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Open access Sep 2026

Mechanistic Insights into Poloxamer 188-Mediated Stabilization of AAV8 Capsids Using Coarse-Grained Molecular Dynamics.

PURPOSE Aggregation of adeno-associated virus (AAV) during manufacturing and storage remains a challenge in gene therapy formulation. This study evaluates how varying Poloxamer188 (P188) concentrations affect the structural stability and aggregation behavior of two full AAV8 capsids. METHODS Coarse-grained molecular...

Leila Sharifi, Jahanbakhsh Ghasemi, Leo Santisi et al. · 0 citations

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