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Author

Leire Arrizabalaga

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Review Oct 2026

A context-dependent framework for targeting NAD metabolism in cancer.

Nicotinamide adenine dinucleotide (NAD) occupies a privileged position at the intersection of cellular bioenergetics, redox homeostasis, and signal transduction. Beyond its canonical role in ATP synthesis, NAD serves as an obligate cofactor for enzymes including poly(ADP-ribose) polymerases (PARPs), sirtuins, and CD38,...

Leire Arrizabalaga, Laura Santambrogio, G. Kroemer et al. · 0 citations

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