Small extracellular vesicles from the plasma of head and neck cancer patients induce dysfunctional T cell phenotypes.
BACKGROUND Head and neck cancer (HNC) is highly immunosuppressive. Despite advances with immune checkpoint (IC) inhibitors, many HNC patients fail to respond. Tumour-derived small extracellular vesicles (sEVs) may contribute to immune evasion and therapy resistance, possibly by altering T-cell phenotypes. METHOD Plas...