Accurate molecular characterization of gliomas is essential for determining prognosis and guiding therapeutic decisions. In recent years, liquid biopsy for analysis of circulating tumor DNA (ctDNA) in blood or cerebrospinal fluid (CSF) has emerged as a promising, minimally invasive alternative. This study evaluat...
Christian Amezquita-Contreras, Angel Bueno, Diego Z. Arellano et al.· Neuro-Oncology Advances· 0 citations
Cell-free total nucleic acid (cfTNA)-based liquid biopsy (LBx) offers a minimally invasive alternative to tissue-based next generation sequencing (NGS). Most NGS-based LBx assays require several days for results. This study validated a rapid NGS-based LBx assay with a two-day turnaround time (TAT). Patient plasma sampl...
S. Roy-Chowdhuri, Ana Galán-Cobo, N. Agarwal et al.· Journal of Molecular Diagnos...· 0 citations
BACKGROUND
Genomic analysis has revealed that approximately 40% of bladder cancer (BLCA) tumors harbor alterations in the PI3K/AKT pathway, with PIK3CA mutations occurring in 15-25% of cases. PIK3CA, which encodes the catalytic p110α subunit of PI3K, plays a critical role in regulating cell survival, proliferation, and...
K. R. Kami Reddy, V. Putluri, D. Piyarathna et al.· Cell communication and signa...· 0 citations
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