Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis.
Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data-independent acquisition (DIA)-based quantitative proteomics to investigat...