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Author

Leonardo Brogliato de Moraes

2 papers indexed here

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Open access Sep 2026

Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis.

Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data-independent acquisition (DIA)-based quantitative proteomics to investigat...

Sarah Fernandes Lima, W. Segura, Leonardo Brogliato de Moraes et al. · 0 citations
Open access Aug 2026

Acidic Stress Induces Proteomic Reprogramming and Virulence-Associated Adaptation in Paracoccidioides brasiliensis.

Findings indicate that Paracoccidioides brasiliensis adapts to acidic environments through coordinated regulation of proteostasis, metabolism, signaling, host-cell interaction, and membrane homeostasis, supporting survival and virulence potential in acidic host microenvironments.

Reinaldo Souza Oliveira, Maria Cecilia Gordijo, W. Segura et al. · 0 citations

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