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Leslie E. Sanderson

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Open access Oct 2026

Somatic TARDBP variants identified in human brain with FTLD-TDP-C disrupt morphology and microglia numbers in zebrafish

Pathogenic germline variants in TARDBP can cause amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Recently, we identified somatic TARDBP variants in the brains of two individuals with semantic dementia and FTLD-TDP type C pathology. These two somatic va...

Leslie E. Sanderson, A. Rajicic, H. C. van der Linde et al. · 0 citations

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