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Leslie Lewis

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Aug 2026

Ciliary ARL13B Drives Cystogenesis in the Kidney via Its GEF Activity.

BACKGROUND Polycystic kidney disease (PKD) is the leading genetic cause of kidney failure, resulting in the accumulation of fluid filled cysts and gross enlargement of the kidney. Mutations in PKD1 or PKD2, which encode ciliary polycystin proteins, are the most common cause of PKD. These proteins function in a cilia-de...

R. V. Van Sciver, Avery Forster, Leslie Lewis et al. · 0 citations

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