Open access
Sep 2026
Structural and functional divergence of cancer hotspot mutations in CREBBP
The crystal structures of recurrent hotspot mutations in the CREBBP acetyltransferase are solved and it is shown that the arginine 1446 hotspot has a unique impact on substrate binding and acetyltransferase activity.
Wen-Chao Zhang, Hao-Peng Yang, Ariel E. Mechaly et al.
· Proceedings of the National... · 0 citations