Author

Leslie S. Kean

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Open access Sep 2026

PTPN2 Deletion Enhances CAR-T Effector Function and CNS Trafficking in a Non-Human Primate Model.

B-cell targeting CAR-T cells (CAR-T) therapies achieve high remission rates, yet durable responses occur in fewer than 40% of patients. Deletion of negative T-cell regulators such as PTPN2, a key inhibitor of TCR and cytokine signaling, represents a promising strategy to enhance CAR-T efficacy. While transfer of PTPN2-...

Francesca Alvarez-Calderon, R. Fleming, Marlana B. Winschel et al. · Blood Advances · 0 citations

Open access Jul 2026

CAR19 Tregs treat murine chronic graft-versus-host disease through immune suppression without measurable B cell cytolysis

The findings suggest that CAR19 Tregs represent a promising and safe cGVHD/BOS therapeutic strategy, offering immunosuppressive benefits and improved disease outcomes that may be more limited with CD8+ CAR19 T cell treatment.

Sujeong Jin, Michael C. Zaiken, Cameron McDonald-Hyman et al. · JCI Insight · 0 citations

Jul 2026

Targeting the Transcription Factor Id2 Reveals Novel Regulatory Mechanisms in Chronic Graft-versus-Host Disease 2257336

Genetic Id2 loss uncouples Tfh differentiation from effector activity, positioning Id2 inhibition as a novel therapeutic strategy to selectively disrupt pathogenic Tfh-GCB crosstalk in cGVHD.

Yujie Zhao, Eun Ko, Cameron McDonald-Hyman et al. · Journal of Immunology · 0 citations