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Lewis C. Cantley

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Jul 2026

Abstract B052: The Kinase Library: A global atlas of the human protein kinome and its applications in drug discovery

Mass-spectrometry-based phosphoproteomics now profiles phosphorylation at proteome scale, yet converting site-level measurements into coherent, kinase-centered biology — and into actionable drug discovery decisions — remains a persistent barrier to target nomination, mechanism-of-action confirmation, and resistance m...

Tomer M. Yaron-Barir, Jared L. Johnson, Lewis C. Cantley · 0 citations
Jul 2026

An AI-enabled structural atlas decodes kinase specificity across the human proteome.

KinoPlex, a computational framework that integrates predicted protein structures and kinase recognition motifs to assign phosphorylation potential and kinase specificity to all serine/threonine/tyrosine residues, is presented.

David Vanderwall, Edward L. Huttlin, J. Mintseris et al. · 0 citations

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