Libin Ye

An Excelled Trifluorinated Probe for GPCR Conformational Quantification

G protein-coupled receptors (GPCRs) represent the largest membrane protein family in the human body and the major targets of FDA-approved medications. Unlike some other physiological proteins, GPCRs are highly plastic and often exist as collections of conformational ensembles in the environment to exert their function....

New paradigm of q-CAR drug development targeting disease-specific protein conformations

Drug discovery has progressed to using advanced AI-driven platforms. These systems rely heavily on static structures and overlook an essential aspect: protein motion—conformational transitions and local fluctuations—is essential for function, as “no motion, no function.” Thus, this review discusses recent progress in m...

Ligand-Specified Signaling Efficacy Defined by Unique Transitions in G Protein Conformations