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Li-Cheng Ren

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Sep 2026

FOXO1 inhibition attenuates ferroptosis-like changes and apoptosis in dopaminergic neurons with the involvement of the SREBP1/SCD1 axis in Parkinson's disease.

Oxidative damage-triggered ferroptosis and apoptosis drive the progression of Parkinson's disease (PD). Forkhead box O1 (FOXO1) is a critical modulator of oxidative stress, while its role in PD remains largely unexplored. Here, the FOXO1 inhibitor AS1842856 (AS) was employed to treat the MPTP-exposed mice and MPP+-chal...

Da-Long He, Yue-Tian Wang, Yi-Min Qiu et al. · 0 citations

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