Author

Li-Dan Yang

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Open access Sep 2026

Identification of Mitochondrial-Lipid Metabolism-Related Diagnostic Targets in Osteoarthritis: Integrative Multi-omics Data and Experimental Validation

Objective Osteoarthritis (OA) is a degenerative joint disease associated with metabolic dysregulation. This study aims to identify mitochondrial-lipid metabolism-related hub genes and explore their mechanisms in OA. Methods Training (GSE55235) and validation (GSE55457 and GSE82107) cohorts were retrieved from the Gene...

Miao Huang, Xu-Tai Tan, Ji-bin Yang et al. · bioRxiv · 0 citations

Review Open access Sep 2026

Context-dependent roles of the NLRP3 inflammasome in osteomyelitis and strategies for precision modulation

Osteomyelitis is an inflammatory bone disease caused by pathogen infection, characterized by persistent infection, bone destruction, and impaired repair. Its refractoriness stems from the interplay between pathogen persistence and dysregulated host immune responses within the unique bone microenvironment. As a critical...

Li-Dan Yang, Lin Zhang, Xu-Xu Yang et al. · Frontiers in Immunology · 0 citations